己酮可可碱与抗血小板聚集剂治疗近期短暂性脑缺血发作（TIA）的随机临床试验。一年随访。

A randomized clinical trial of pentoxifylline and antiaggregants in recent transient ischemic attacks (TIA). A one year follow-up.

作者信息

Herskovits E, Vazquez A, Famulari A, Tamaroff L, Fraiman H, Gonzáles A M, Smud R, Vila J, Matera V

出版信息

Ric Clin Lab. 1981;11 Suppl 1:257-64.

Abstract

A multicenter comparative trial was conducted in patients with transient ischemic attacks (TIA) to study the preventive capacity of a combination of acetylsalicylic acid and dipyridamol (1,050 mg + 150 mg/day - group A) and of pentoxifylline (1,200 mg/day - group P) in the reduction of morbidity rates. Sixty-six patients, 36 on A and 30 on P, were evaluated. There was no statistically significant difference between both groups as regards age, sex, blood pressure, localisation of TIA and incidence of risk factors. Incidence of new ischemic events during a one year follow up period in the A-group was 28% compared to 10% in the P-group, this difference being statistically significant in favour of P (p less than 0.05). Stroke incidence was similar in both groups but distinctly lower (4.5%) than the natural frequency in TIA.

摘要

在短暂性脑缺血发作（TIA）患者中进行了一项多中心对比试验，以研究阿司匹林与双嘧达莫联合用药（1050毫克 + 150毫克/天 - A组）和己酮可可碱（1200毫克/天 - P组）降低发病率的预防能力。对66例患者进行了评估，其中36例在A组，30例在P组。两组在年龄、性别、血压、TIA的部位以及危险因素的发生率方面无统计学显著差异。A组在一年随访期内新缺血事件的发生率为28%，而P组为10%，这一差异在统计学上对P组有利（p小于0.05）。两组的中风发生率相似，但明显低于TIA的自然发生率（4.5%）。