Bergsten P, Berggren P O, Larsson R, Gylfe E
Acta Biol Med Ger. 1982;41(12):1225-8.
The interactions between Mg2+ and Ca2+ and the total content of magnesium were studied in beta-cell-rich pancreatic islets from ob/ob mice. High concentrations of Mg2+ inhibited basal intracellular 45Ca net uptake as well as that stimulated by K+ depolarization or Na+ omission, suggesting that Ca2+ and Mg2+ can compete for both the voltage-dependent Ca2+ and the Na+ channels. The magnesium content of the islets was remarkably stable being affected only under extreme conditions. It is suggested that the physiological stimulation of insulin secretion does not depend on dynamic fluctuations of magnesium metabolism.
研究了ob/ob小鼠富含β细胞的胰岛中Mg2+与Ca2+之间的相互作用以及镁的总含量。高浓度的Mg2+抑制基础细胞内45Ca的净摄取以及由K+去极化或Na+缺失所刺激的摄取，这表明Ca2+和Mg2+可竞争电压依赖性Ca2+通道和Na+通道。胰岛中的镁含量非常稳定，仅在极端条件下才会受到影响。提示胰岛素分泌的生理刺激不依赖于镁代谢的动态波动。
