大鼠昼夜代谢周期的神经内分泌基础的各个方面。

Aspects of the neuroendocrine bases of the diurnal metabolic cycle in rats.

作者信息

Penicaud L, Le Magnen J

出版信息

Neurosci Biobehav Rev. 1980;4 Suppl 1:39-42. doi: 10.1016/0149-7634(80)90046-9.

Abstract

The difference between nocturnal and diurnal glucose disappearance rate, glucose stimulated insulin release and insulin sensitivity has been studied in normal adult female rats. The glucose clearance rate measured after an IV injection of glucose (1 g/kg) was found to be slower during the day than at night. However, due to the non-physiological level of hyperglycemia induced, the insulinogenic index failed to reveal a difference in glucose stimulated insulin release. On the contrary, the hypoglycemic response to an IV injection of 0.5 IU/kg of insulin indicated a higher insulin sensitivity and tissue glucose uptake at night compared to the day. The results are discussed with respect to the role of the neuroendocrine diurnal pattern underlying the diurnal periodicity of feeding.

摘要

在正常成年雌性大鼠中，对夜间和日间葡萄糖消失率、葡萄糖刺激的胰岛素释放以及胰岛素敏感性之间的差异进行了研究。静脉注射葡萄糖（1 g/kg）后测得的葡萄糖清除率在白天比夜间慢。然而，由于诱导的高血糖水平不符合生理状态，胰岛素生成指数未能显示出葡萄糖刺激的胰岛素释放在日间存在差异。相反，静脉注射0.5 IU/kg胰岛素后的低血糖反应表明，与白天相比，夜间胰岛素敏感性更高，组织对葡萄糖的摄取也更多。针对进食昼夜节律背后的神经内分泌昼夜模式的作用对结果进行了讨论。