Maneschi F, Fineberg S E, Kohner E M
Diabetes Care. 1982 Nov-Dec;5 Suppl 2:175-9. doi: 10.2337/diacare.5.2.s175.
An 82-yr-old woman with type II diabetes developed antibody-mediated insulin resistance while on mixed pork-beef insulin concomitantly with a non-Hodgkin lymphoma. Insulin resistance was initially treated with highly purified pork insulin, but this was unsuccessful. Treatment with human insulin (recombinant DNA) was associated with marked decrease of both insulin requirement and high-affinity antibodies, increase of free insulin levels, and improvement of diabetic control. This patient's case shows that human insulin can be considered as an alternative treatment for immune-mediated insulin resistance.
一名82岁的II型糖尿病女性在使用混合猪肉-牛肉胰岛素的同时患有非霍奇金淋巴瘤，出现了抗体介导的胰岛素抵抗。胰岛素抵抗最初用高纯度猪胰岛素治疗，但未成功。使用人胰岛素（重组DNA）治疗与胰岛素需求量和高亲和力抗体显著降低、游离胰岛素水平升高以及糖尿病控制改善有关。该患者的病例表明，人胰岛素可被视为免疫介导的胰岛素抵抗的替代治疗方法。
