海马锥体神经元自发性爆发的内源性本质。
Endogenous nature of spontaneous bursting in hippocampal pyramidal neurons.
作者信息
Hablitz J J, Johnston D
机构信息
Department of Neurology, Baylor College of Medicine, Houston, Texas 77030.
出版信息
Cell Mol Neurobiol. 1981 Dec;1(4):325-34. doi: 10.1007/BF00716267.
Abstract
The normal spontaneous bursting behavior of hippocampal pyramidal neurons was investigated. Bursting frequency was found to be membrane potential dependent, the frequency increasing with maintained depolarization and decreasing upon hyperpolarization. Short depolarizing-current pulses would trigger bursts which outlasted the stimulus, and bursting continued when synaptic transmission had been blocked. The spontaneous bursts of these neurons, in contrast to bursts induced by convulsive agents, appear to exhibit the classical behavior of endogenous bursts as observed in invertebrate neurons. The endogenous bursts in hippocampal neurons may result, also, from an interplay of intrinsic membrane currents.
摘要
研究了海马锥体神经元正常的自发放电行为。发现放电频率依赖于膜电位，频率随持续去极化而增加，随超极化而降低。短的去极化电流脉冲会触发持续时间超过刺激的放电，并且当突触传递被阻断时放电仍会继续。与惊厥剂诱导的放电相比，这些神经元的自发放电似乎表现出在无脊椎动物神经元中观察到的内源性放电的经典行为。海马神经元中的内源性放电也可能源于内在膜电流的相互作用。
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