Chuppina L M
Zh Evol Biokhim Fiziol. 1978 Jul-Aug;14(4):365-9.
In experiments on newborn rabbits under nembutal (pentobarbital) anaesthesia, studies have been made on changes of visual evoked potential in the visual cortex during application of 1% solutions of GABA and nembutal. At the age of 7--9 days, these drugs decreased the evoked response, which may be associated with their hyperpolarizing effect on cortical synapses. Between the 11th and the 13th days, no effect of GABA and nembutal upon the evoked potential was noted. Definitive reaction to application of these pharmacological drugs typical for adult animals is formed not earlier than to the 15th--17th day. Beginning from this time, application of GABA and nembutal significantly increases visual evoked potential. The postnatal evolution of chemical sensitivity of postsynaptic membrane of neurons of the visual cortex in rabbits is discussed.
在戊巴比妥（戊巴比妥钠）麻醉下对新生兔进行的实验中，研究了在应用1% GABA溶液和戊巴比妥期间视觉皮层中视觉诱发电位的变化。在7 - 9日龄时，这些药物降低了诱发电反应，这可能与其对皮层突触的超极化作用有关。在第11至13天之间，未观察到GABA和戊巴比妥对诱发电位的影响。对这些成年动物典型的药理药物应用的明确反应直到第15 - 17天才形成。从这个时候开始，应用GABA和戊巴比妥显著增加视觉诱发电位。文中讨论了兔视觉皮层神经元突触后膜化学敏感性的出生后演变。
