在存在家族性血红蛋白病哈沙龙和家族性高铁血红蛋白还原酶缺乏的情况下，氨苯砜诱发的高铁血红蛋白血症和溶血。
Dapsone-induced methemoglobinemia and hemolysis in the presence of familial hemoglobinopathy Hasharon and familial methemoglobin reductase deficiency.
作者信息
Ganer A, Knobel B, Fryd C H, Rachmilewitz E A
出版信息
Isr J Med Sci. 1981 Aug;17(8):703-4.
PMID:6765904
Abstract
Methemoglobinemia and hemolysis are well-known side effects after using high doses of dapsone (4,4'-diaminodiphenylsulfone). Their occurrence after low doses of the drug, and subsequent investigation, revealed the presence of hemoglobin Hasharon, and low content of NADH-dependent methemoglobin reductase in five members of an East European ashkenazic Jewish family.
摘要
使用高剂量氨苯砜（4,4'-二氨基二苯砜）后，高铁血红蛋白血症和溶血是众所周知的副作用。在使用低剂量该药后出现这些症状，并随后进行调查，结果显示一个东欧阿什肯纳兹犹太家庭的五名成员存在血红蛋白哈沙龙，且NADH依赖性高铁血红蛋白还原酶含量较低。
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