Rigo J, Senterre J
JPEN J Parenter Enteral Nutr. 1980 Jan-Feb;4(1):15-7. doi: 10.1177/014860718000400105.
Serum threonine concentration was determined during the first month of life in 163 low birthweight infants fed on either human milk, various adapted formulae, or total parenteral nutrition. On the pooled data, a significant positive relationship was found between the serum threonine concentration and threonine intake. However, the increase of the serum threonine level is more marked in the infants with the lowest actual gestational age; with a high threonine intake, the most premature infants have serum threonine levels twice as high (58.1 vs 31.7 microM/dl) as term infants. Therefore, threonine metabolism seems to be impeded in preterm infants. Considering the cord blood concentration of threonine (26.8 +/- 5.1 microM/dl) and the possible hazardous effect of hyperthreoninemia, it is suggested that threonine intake should not exceed 1200 microM (143 mg)/kg bodyweight/day in premature infants and that the amino acid composition of the diet should probably be modified in order to satisfy their protein requirement.
对163名低体重出生婴儿在出生后第一个月内的血清苏氨酸浓度进行了测定，这些婴儿分别喂养母乳、各种配方奶或接受全胃肠外营养。综合数据显示，血清苏氨酸浓度与苏氨酸摄入量之间存在显著的正相关关系。然而，实际胎龄最小的婴儿血清苏氨酸水平升高更为明显；苏氨酸摄入量较高时，极早产儿的血清苏氨酸水平是足月儿的两倍（58.1对31.7微摩尔/分升）。因此，早产儿的苏氨酸代谢似乎受到阻碍。考虑到脐带血中苏氨酸的浓度（26.8±5.1微摩尔/分升）以及高苏氨酸血症可能产生的有害影响，建议早产儿的苏氨酸摄入量不应超过1200微摩尔（143毫克）/千克体重/天，并且可能需要调整饮食的氨基酸组成以满足其蛋白质需求。
