Zeitoun P, Rigot J J, Garbe E, Nasca S
Nouv Presse Med. 1980 Feb 9;9(7):421-5.
Malnutrition and cachexia are major consequences of neoplastic diseases. When a response to one or more forms of oncologic therapy is expected, simultaneous application of artificial nutrition is often needed. Continuous pump-tube enteric alimentation is an efficient, well tolerated method which is easy to perform in a medical ward. We fed 29 patients with this technique during a mean of 43,6 days and a daily intake of more than 3500 Kcal. We noticed the following observations: -- when out of the impact of any therapy directed against the tumor the 21 patients with advanced cancers demonstrated an ability to gain weight and to achieve a positive nitrogen balance equivalent to that performed by the 8 non tumor-bearing patients; -- radiation therapy, administered to the head, neck and thorax resulted in an increase of energetic expenditure; -- chemotherapy impairs for a few days the benefits of the enteric alimentation. This paper underlines the possibility of nutritional rehabilitation of patients with a cancer cachexia. The metabolic injury produced by chemotherapy and radiation therapy increases the need for an afficient treatment of the malnutrition in cancer.
营养不良和恶病质是肿瘤疾病的主要后果。当预期对一种或多种肿瘤治疗形式有反应时,通常需要同时进行人工营养支持。持续泵管肠内营养是一种高效、耐受性良好的方法,在医疗病房中易于实施。我们用这种技术喂养了29名患者,平均喂养43.6天,每日摄入量超过3500千卡。我们观察到以下情况:——在任何针对肿瘤的治疗影响之外,21例晚期癌症患者表现出体重增加的能力,并实现了与8例非肿瘤患者相当的正氮平衡;——对头、颈和胸部进行放射治疗导致能量消耗增加;——化疗在几天内会损害肠内营养的益处。本文强调了癌症恶病质患者营养康复的可能性。化疗和放疗产生的代谢损伤增加了对癌症患者营养不良进行有效治疗的需求。