Serabjit-Singh C J, Wolf C R, Philpot R M, Plopper C G
Science. 1980 Mar 28;207(4438):1469-70. doi: 10.1126/science.6767272.
Cytochrome P-450-dependent monooxygenase systems, which metabolize endogenous as well as foriegn compounds, are found in hepatic and several extrahepatic tissues of mammals, including humans. A form of cytochrome P-450 is localized in the nonciliated bronchiolar epithelial cells (Clara cells) of the small airways of rabbit lung. The apparent high concentration of the cytochrome in this pulmonary cell type compared to liver may be an important determinant in the susceptibility of the lung to a number of toxic chemicals that undergo metabolic activation.
细胞色素P - 450依赖性单加氧酶系统可代谢内源性和外源性化合物，存在于包括人类在内的哺乳动物的肝脏及几种肝外组织中。一种细胞色素P - 450定位于兔肺小气道的无纤毛细支气管上皮细胞（克拉拉细胞）中。与肝脏相比，这种肺细胞类型中细胞色素的明显高浓度可能是肺对许多经代谢活化的有毒化学物质易感性的一个重要决定因素。
