Srivastava K, Dasgupta P K
Indian J Physiol Pharmacol. 1980 Jan-Mar;24(1):43-8.
Centchroman studied at various doses did not cause ovulation in immature rats as judged by morphological, histological and biochemical parameters whereas, 20 mg/kh dose caused early opening of vagina and cornification of the vaginal epithelial cells. However, no ovulation was detected by this regimen. No stimulatory effect was observed in the glycogen and cholesterol content in the ovaries of Centchroman treated rats. The effects on vagina persisted even in ovariectomised immature rats administered with Centchroman. The mode of various doses of Centchroman in immature rats as judged morphologically, histologically and biochemically has been discussed.
根据形态学、组织学和生化参数判断，不同剂量的醋炔醚对未成熟大鼠均未引起排卵，而20mg/kg剂量可导致阴道过早开放及阴道上皮细胞角化。然而，该给药方案未检测到排卵现象。在给予醋炔醚的大鼠卵巢中，未观察到糖原和胆固醇含量有刺激作用。即使对去卵巢的未成熟大鼠给予醋炔醚，对阴道的作用依然存在。本文已从形态学、组织学和生化方面对不同剂量醋炔醚在未成熟大鼠中的作用方式进行了讨论。
