Knauf H, Steim H
MMW Munch Med Wochenschr. 1980 Jan 25;122(4):133-6.
The effect of the combination preparation Moducrin on the blood pressure in the course of the day, the heart rate and the routine blood parameters was investigated in 25 patients with essential hypertension. The blood pressure was shown to be completely stable in the daily profile and was almost equally high in standing and supine position. The electrolyte balance remained constant in all cases. Only the serum uric acid and the creatinine rose negligibly during the treatment. The studies have shown that in 80% of patients with essential hypertension a constant lowering of blood pressure throughout the day could be achieved with one tablet of Moducrin, without upsetting the electrolyte balance.