纳洛酮对哌醋甲酯所致情绪和行为变化的影响：一项阴性研究。
The effects of naloxone on methylphenidate-induced mood and behavioral changes: a negative study.
作者信息
Huey L Y, Janowsky D S, Judd L L, Roitman N A, Clopton P L, Segal D, Hall L, Parker D
出版信息
Psychopharmacology (Berl). 1980 Feb;67(2):125-30. doi: 10.1007/BF00431966.
PMID:6768088
Abstract
The effects of naloxone on IV methylphenidate-induced mood, behavior, and neurohumoral changes were assessed in eight psychiatric inpatients. While methylphenidate alone produced anticipated changes, the indications for significant naloxone-methylphenidate interactions were minimal. It is speculated that larger doses of naloxone might be required to produce modification of the psychostimulant effects.
摘要
在八名精神科住院患者中评估了纳洛酮对静脉注射哌醋甲酯引起的情绪、行为和神经体液变化的影响。虽然单独使用哌醋甲酯产生了预期的变化，但纳洛酮与哌醋甲酯显著相互作用的迹象微乎其微。据推测，可能需要更大剂量的纳洛酮才能改变精神兴奋剂的作用。
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