Tsokos G, Papamichail M, Fessas P
Acta Haematol. 1980;63(2):88-93. doi: 10.1159/000207376.
We present the immunological studies on 2 patients, one with the Wiskott-Aldrich syndrome and another with common variable hypogammaglobulinemia. Although these patients represent two different immunodeficiency defects, both had a subpopulation of peripheral lymphocytes which had simultaneously T and B characteristics. Their peripheral blood mononuclear cells had a low responsiveness to polyclonal mitogens. We suggest that these unusual cells represent a subpopulation of suppressor cells or of immature T cells, which may have an essential role in the pathogenesis of these immunodeficiencies.
我们展示了对两名患者的免疫学研究，一名患有维斯科特-奥尔德里奇综合征，另一名患有常见变异型低丙种球蛋白血症。尽管这些患者代表了两种不同的免疫缺陷，但他们外周淋巴细胞的一个亚群同时具有T细胞和B细胞特征。他们的外周血单核细胞对多克隆有丝分裂原的反应性较低。我们认为，这些异常细胞代表了抑制细胞或未成熟T细胞的一个亚群，它们可能在这些免疫缺陷的发病机制中起重要作用。
