Laitinen M, Nieminen M, Hietanen E, Hänninen O
Acta Pharmacol Toxicol (Copenh). 1980 Apr;46(4):283-8. doi: 10.1111/j.1600-0773.1980.tb02455.x.
The effects of seasonal feeding on the structure and function of the hepatic microsomes of the reindeer were studied. In native microsomes the protein content did not vary depending on seasonal feeding, but there was a slight modification of the lipid moiety. The sensitivity of microsomes to membrane treatments changed from season to season. Seasonal feeding did not affect the hepatic cytochrome c reductase activity. However, the poor winter food depressed UDPglucuronosyltransferase activity to one third of that after summer feeding. The UDPglucuronosyltransferase activity was lower in both native and treated microsomes. No differences were found in serum activities of aspartate or alanine aminotransferase although there were changes in the structure and function of hepatocytes. The poor winter feeding of the reindeer decreases their capacity to glucuronate foreign compounds and this is mediated by structural modification on the hepatic endoplasmic reticulum.
研究了季节性饲养对驯鹿肝微粒体结构和功能的影响。在天然微粒体中，蛋白质含量并不随季节性饲养而变化，但脂质部分有轻微改变。微粒体对膜处理的敏感性随季节变化。季节性饲养不影响肝细胞色素c还原酶活性。然而，冬季食物匮乏使UDP葡萄糖醛酸转移酶活性降至夏季饲养后的三分之一。UDP葡萄糖醛酸转移酶活性在天然和处理后的微粒体中均较低。尽管肝细胞的结构和功能发生了变化，但天冬氨酸或丙氨酸转氨酶的血清活性未发现差异。驯鹿冬季食物匮乏会降低它们使外来化合物葡萄糖醛酸化的能力，这是由肝内质网的结构改变介导的。
