• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

野生和半家养驯鹿(驯鹿属)葡萄糖醛酸化率及内质网组成的变化

Variations in the glucuronidation rate and in the composition of the endoplasmic reticulum of the wild and semi-domestic reindeer (Rangifer tarandus).

作者信息

Laitinen M, Nieminen M, Hietanen E

出版信息

Comp Biochem Physiol B. 1982;71(3):527-30. doi: 10.1016/0305-0491(82)90422-9.

DOI:10.1016/0305-0491(82)90422-9
PMID:6802565
Abstract
  1. The activity of UDPglucuronosyltransferase was analyzed in the hepatic and renal microsomes and in the postmitochondrial supernatant fraction of the duodenal mucosa of wild and semi-domestic reindeer. 2. The total activity was about the same in the hepatic microsomes of both animal groups. When the specific activity was analyzed, the semi-domestic reindeer showed twice as high activities as the wild ones. 3. The results in the kidney and duodenum showed similar changes. 4. The protein, cholesterol and phospholipid concentrations of microsomal and postmitochondrial supernatant preparations were higher in the wild reindeer. 5. It is concluded on the basis of present results that the in vitro glucuronidation in the wild reindeer is on a lower level than in the semi-domestic ones. 6. This might be a consequence of changed membrane structure where UDPglucuronosyltransferase is located.
摘要
  1. 对野生和半家养驯鹿的肝脏和肾脏微粒体以及十二指肠黏膜的线粒体后上清液部分中的尿苷二磷酸葡萄糖醛酸基转移酶活性进行了分析。2. 两组动物肝脏微粒体中的总活性大致相同。在分析比活性时,半家养驯鹿的活性是野生驯鹿的两倍。3. 肾脏和十二指肠中的结果显示出类似的变化。4. 野生驯鹿微粒体和线粒体后上清液制剂中的蛋白质、胆固醇和磷脂浓度较高。5. 根据目前的结果得出结论,野生驯鹿的体外葡萄糖醛酸化水平低于半家养驯鹿。6. 这可能是尿苷二磷酸葡萄糖醛酸基转移酶所在膜结构发生变化的结果。

相似文献

1
Variations in the glucuronidation rate and in the composition of the endoplasmic reticulum of the wild and semi-domestic reindeer (Rangifer tarandus).野生和半家养驯鹿(驯鹿属)葡萄糖醛酸化率及内质网组成的变化
Comp Biochem Physiol B. 1982;71(3):527-30. doi: 10.1016/0305-0491(82)90422-9.
2
On the effects of nutrition on the metabolism of foreign compounds in the liver of reindeer (Rangifer tarandus tarandus L).关于营养对驯鹿(Rangifer tarandus tarandus L.)肝脏中外源化合物代谢的影响
Acta Pharmacol Toxicol (Copenh). 1980 Apr;46(4):283-8. doi: 10.1111/j.1600-0773.1980.tb02455.x.
3
Glucuronidation in the reindeer: dietary modification in the UDP-glucuronosyltransferase activity with 4-nitrophenol, 1-naphthol and phenolphthalein as acceptors.驯鹿中的葡萄糖醛酸化作用:以4-硝基苯酚、1-萘酚和酚酞为受体时,饮食改变对UDP-葡萄糖醛酸基转移酶活性的影响
Int J Biochem. 1984;16(10):1083-6. doi: 10.1016/0020-711x(84)90092-2.
4
6 alpha-glucuronidation of hyodeoxycholic acid by human liver, kidney and small bowel microsomes.人肝脏、肾脏和小肠微粒体对猪去氧胆酸的6α-葡萄糖醛酸化作用。
Biochim Biophys Acta. 1987 Sep 25;921(2):392-7. doi: 10.1016/0005-2760(87)90041-5.
5
Hepatic and duodenal drug metabolism in the rat during fat deficiency.大鼠脂肪缺乏期间肝脏和十二指肠的药物代谢
Gen Pharmacol. 1976 Sep;7(4):263-6. doi: 10.1016/0306-3623(76)90086-0.
6
Nuclear membrane-bound UDPglucuronosyltransferase of rat liver.大鼠肝脏的核膜结合型尿苷二磷酸葡萄糖醛酸基转移酶
Can J Biochem. 1982;60(10):972-8. doi: 10.1139/o82-125.
7
Expression of MCT1, MCT2 and MCT4 in the rumen, small intestine and liver of reindeer (Rangifer tarandus tarandus L.).MCT1、MCT2和MCT4在驯鹿(Rangifer tarandus tarandus L.)瘤胃、小肠和肝脏中的表达。
Comp Biochem Physiol A Mol Integr Physiol. 2005 May;141(1):29-34. doi: 10.1016/j.cbpb.2005.03.003.
8
Hepatic and extrahepatic glucuronidation of bile acids in man. Characterization of bile acid uridine 5'-diphosphate-glucuronosyltransferase in hepatic, renal, and intestinal microsomes.人体内胆汁酸的肝脏和肝外葡萄糖醛酸化。肝脏、肾脏和肠道微粒体中胆汁酸尿苷5'-二磷酸葡萄糖醛酸基转移酶的特性。
J Clin Invest. 1984 Aug;74(2):402-10. doi: 10.1172/JCI111435.
9
Effective glucuronidation of 6 alpha-hydroxylated bile acids by human hepatic and renal microsomes.人肝微粒体和肾微粒体对6α-羟基化胆汁酸的有效葡萄糖醛酸化作用。
Eur J Biochem. 1988 Jan 15;171(1-2):329-34. doi: 10.1111/j.1432-1033.1988.tb13794.x.
10
Dietary fats and properties of endoplasmic reticulum: II. Dietary lipid induced changes in activities of drug metabolizing enzymes in liver and duodenum of rat.膳食脂肪与内质网的特性:II. 膳食脂质诱导大鼠肝脏和十二指肠中药物代谢酶活性的变化
Lipids. 1975 Aug;10(8):467-72. doi: 10.1007/BF02532430.