Levy L, Wicke J D
Ann Neurol. 1980 Feb;7(2):150-6. doi: 10.1002/ana.410070210.
A thermal diffusion probe, with cannulas for intracerebral microinfusion of drugs and an electrode to monitor electroencephalographic (EEG) activity, was used to examine the local effect of vasoactive amines in a 4 to 5 mm sphere of caudate nucleus in cats. The results demonstrated that it is possible to alter local cerebral blood flow (CBF) without causing any change in systemic blood pressure or heart rate, or in CBF and the EEG in the opposite caudate. One-microliter intracerebral injections, containing varying amounts of phenylephrine, increased local CBF in proportion to dose. The effect was blocked by intracerebral infusion of phentolamine. However, local alpha-adrenergic blockade did not inhibit vascular responses to blood pressure elevation or to metabolic influences on local blood flow.
一种热扩散探针，带有用于脑内微量注射药物的套管和一个监测脑电图（EEG）活动的电极，被用于研究血管活性胺在猫尾状核4至5毫米范围内的局部作用。结果表明，有可能改变局部脑血流量（CBF），而不会引起全身血压、心率的任何变化，也不会引起对侧尾状核的CBF和EEG的变化。含不同剂量去氧肾上腺素的1微升脑内注射，使局部CBF按剂量比例增加。该效应被脑内注入酚妥拉明所阻断。然而，局部α-肾上腺素能阻断并不抑制对血压升高或对局部血流代谢影响的血管反应。
