Solomon L, Eng A M, Bené M, Loeffel E D
Arch Dermatol. 1980 Mar;116(3):318-20.
A patient with a variety of nevus cell nevi, a congenital giant melanocytic nevus, abnormal facies, vascular anomaly of the leg, and mental retardation was examined. The patient also had neuroid elements within the giant nevus that led to the consideration of neurofibromatosis. Because neurofibromatosis is a genetically determined condition with tissue different from the neuroid elements seen in giant nevi, the two conditions are considered to be different entities. Malignant transformation of congenital giant pigmented nevi occurs, although the incidence of such transformation remains a subject of controversy.
对一名患有多种痣细胞痣、先天性巨大黑素细胞痣、面容异常、腿部血管异常和智力发育迟缓的患者进行了检查。该患者在巨大痣内还存在神经样成分，这导致了对神经纤维瘤病的考虑。由于神经纤维瘤病是一种由基因决定的疾病，其组织与在巨大痣中所见的神经样成分不同，因此这两种疾病被认为是不同的实体。先天性巨大色素痣会发生恶性转化，尽管这种转化的发生率仍然存在争议。
