Pardini R S, Heidker J C, Baker T A, Payne B
Arch Environ Contam Toxicol. 1980;9(1):87-97. doi: 10.1007/BF01055502.
The effect of various pesticides and derivatives on mitochondrial electron transport systems was assessed. DDT, DDE, TDE, Kelthane, chlorobenzilate, chloropropylate and Acarol were found to be inhibitory towards both heavy beef heart mitochondrial (HBHM) NADH-oxidase and succinoxidase enzyme systems. Dichlorobenzophenone and p-chlorophenol were less inhibitory towards the HBHM NADH-oxidase and did not inhibit the succinoxidase enzyme system. DDA did not inhibit either of the electron transport systems. Carbaryl was not inhibitory towards both HBHM oxidase systems, whereas its degradative product dihydroxynaphthalene was inhibitory at the same concentration. Furadan, Matacil, Baygon and Dimetilan were only slightly inhibitory towards themitochondrial NADH-oxidase system and did not inhibit the succinoxidase system. Zectran was inhibitory towards the NADH-oxidase system and was not inhibitory towards the succinoxidase system. DDT, DDE and TDE, dihydroxynaphthalene and 1-naphthol inhibited the NADH-oxidase enzyme system onthe substrate side of cytochrome c, whereas Kelthane inhibited on the oxygen side.
评估了各种农药及其衍生物对线粒体电子传递系统的影响。发现滴滴涕（DDT）、滴滴伊（DDE）、滴滴滴（TDE）、三氯杀螨醇、乙酯杀螨醇、丙酯杀螨醇和杀螨酯对重型牛心线粒体（HBHM）NADH氧化酶和琥珀酸氧化酶系统均有抑制作用。二氯二苯甲酮和对氯苯酚对HBHM NADH氧化酶的抑制作用较小，且不抑制琥珀酸氧化酶系统。滴滴胺（DDA）对任何一个电子传递系统均无抑制作用。西维因对HBHM的两种氧化酶系统均无抑制作用，而其降解产物二羟基萘在相同浓度下具有抑制作用。呋哺丹、灭草灵、拜耳驱虫菊酯和胺甲萘仅对线粒体NADH氧化酶系统有轻微抑制作用，且不抑制琥珀酸氧化酶系统。皮蝇磷对NADH氧化酶系统有抑制作用，对琥珀酸氧化酶系统无抑制作用。DDT、DDE和TDE、二羟基萘和1-萘酚在细胞色素c的底物侧抑制NADH氧化酶系统，而三氯杀螨醇在氧侧抑制该系统。
