Baumann R, Kuhl H, Taubert H D, Sandow J
Contraception. 1980 Feb;21(2):191-7. doi: 10.1016/0010-7824(80)90131-6.
A highly active LH-RH-analog (D-Ser(TBU)6-LH-RH-(1-9)-nonapeptide-ethylamide = HOE 766) was administered to normally cyclic and ovulatory women in a double-blind study. Each woman received from day 1 through day 14 of the cycle according to a randomization plan either 10 microgram HOE 766 i.m. or a placebo. Ovulation was inhibited for at least two weeks in all subjects receiving HOE 766. The initially very marked release of LH measured 4 hourse after the injection decreased within 3 days by approximately 50%, and remained at this level for the remainder of the experiment while the initially high FSH response was abolished during further treatment. In 3 out of 5 women receiving the analog, serum estradiol was severely suppressed, in the remaining 2 slightly. Within 5 days after the discontinuation of treatment, the pituitary had regained the capacity to respond normally to LH-RH. It is postulated that follicular maturation is disturbed by the unphysiologic pattern of gonadotropin secretion during administration of HOE 766.
在一项双盲研究中，对月经周期正常且有排卵功能的女性施用了一种高活性的促黄体生成激素释放激素类似物（D-丝氨酸（叔丁基）6-促黄体生成激素释放激素-（1-9）-九肽乙酰胺 = HOE 766）。根据随机化方案，每位女性在月经周期的第1天至第14天，肌肉注射10微克HOE 766或安慰剂。所有接受HOE 766的受试者排卵均被抑制至少两周。注射后4小时测得的促黄体生成素最初非常显著的释放量在3天内下降了约50%，并在实验剩余时间内维持在该水平，而最初较高的促卵泡生成素反应在进一步治疗期间消失。在接受该类似物的5名女性中，有3名女性的血清雌二醇受到严重抑制，其余2名受抑制程度较轻。在停药后5天内，垂体恢复了对促黄体生成激素释放激素正常反应的能力。据推测，在施用HOE 766期间，促性腺激素分泌的非生理模式扰乱了卵泡成熟。
