Castaldi P A, Smith I L
Pathology. 1980 Jan;12(1):111-8. doi: 10.3109/00313028009060059.
Incubation of prothrombin complex concentrates, both non-activated and activated, in plasma enhances coagulation. The effect is reduced with time and is augmented when platelets are present. Such concentrates correct the coagulation abnormality in vitro in haemophilic plasmas with factor VIII inhibitors and the correction is greater in platelet rich than platelet poor plasma. Platelets appear to protect incubated concentrates from inhibitors present in plasma. Platelets may play a role in mediating the in vivo clot-promoting activity of some components of these concentrates. This effect may contribute to unwanted thrombosis or, conversely, may facilitate the sometimes-observed haemostatic effect of concentrates in patients with inhibitors of factor VIII.
非活化和活化的凝血酶原复合物浓缩物在血浆中孵育可增强凝血作用。随着时间推移，这种作用会减弱，而当有血小板存在时则会增强。此类浓缩物可在体外纠正存在因子VIII抑制剂的血友病血浆中的凝血异常，且在富含血小板的血浆中比在血小板缺乏的血浆中的纠正作用更强。血小板似乎能保护孵育的浓缩物免受血浆中存在的抑制剂影响。血小板可能在介导这些浓缩物某些成分的体内促凝活性中发挥作用。这种作用可能导致不必要的血栓形成，或者相反，可能有助于在有因子VIII抑制剂的患者中有时观察到的浓缩物的止血作用。
