阿霉素对非人灵长类动物的心脏毒性及可能的致白血病作用。

Cardiotoxic and possible leukemogenic effects of adriamycin in nonhuman primates.

作者信息

Sieber S M, Correa P, Young D M, Dalgard D W, Adamson R H

出版信息

Pharmacology. 1980;20(1):9-14. doi: 10.1159/000137337.

Abstract

10 monkeys (macaques) received adriamycin by monthly intravenous injections at 12 mg/m2 (1 mg/kg). 8 of the 10 monkeys developed congestive heart failure at an average cumulative adriamycin dose (310 mg/m2) well below that considered the safe upper limit (550 mg/m2) in man. Histologically, the myocardial lesions resembled those found in human anthracycline-induced cardiomyopathy. 1 of the 10 monkeys developed acute myeloblastic leukemia after receiving 324 mg/m2 of adriamycin; the 10th monkey is alive and well 26 months after the last dose of drug. Our results suggest that adriamycin is a more potent cardiotoxin in monkeys than in man, and that leukemia may be a consequence of prolonged treatment with this drug.

摘要

10只猴子（猕猴）每月静脉注射阿霉素，剂量为12 mg/m²（1 mg/kg）。10只猴子中有8只在平均累积阿霉素剂量（310 mg/m²）远低于人类认为的安全上限（550 mg/m²）时出现了充血性心力衰竭。组织学上，心肌病变类似于人类蒽环类药物诱导的心肌病中发现的病变。10只猴子中有1只在接受324 mg/m²阿霉素后发生了急性髓细胞白血病；第10只猴子在最后一剂药物注射26个月后仍存活且健康。我们的结果表明，阿霉素对猴子的心脏毒性比对人类更强，白血病可能是长期使用这种药物的结果。