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单胺氧化酶底物与底物亲和力。

Monoamine oxidase substrates and substrate affinity.

作者信息

Domino E F

出版信息

Schizophr Bull. 1980;6(2):292-7. doi: 10.1093/schbul/6.2.292.

DOI:10.1093/schbul/6.2.292
PMID:6769148
Abstract

The evidence that there are two forms of monoamine oxidase (MAO) enzymes is reviewed. On the basis of various substrate affinities, differential inhibition by deprenyl and clorgyline, and heat inactivation, there appear to be a type A and a type B MAO in various tissues. The enzymatic oxidation of telemethylhistamine (tMH) is an example of an endogenous substrate for type B MAO.

摘要

对存在两种单胺氧化酶(MAO)形式的证据进行了综述。基于各种底物亲和力、司来吉兰和氯吉兰的差异抑制以及热失活,在各种组织中似乎存在A型和B型MAO。远端甲基组胺(tMH)的酶促氧化是B型MAO内源性底物的一个例子。

相似文献

1
Monoamine oxidase substrates and substrate affinity.单胺氧化酶底物与底物亲和力。
Schizophr Bull. 1980;6(2):292-7. doi: 10.1093/schbul/6.2.292.
2
[Possible mechanism of selective inhibition of rat liver mitochondrial monoamine oxidase by chlorgiline and deprenyl].[氯吉兰和司来吉兰对大鼠肝线粒体单胺氧化酶的选择性抑制作用机制]
Biokhimiia. 1979 Feb;44(2):195-207.
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Preferential localization of monoamine oxidase type A activity in neurons of the locus coeruleus and type B activity in neurons of the dorsal raphe nucleus of the rat: a detailed enzyme histochemical study.大鼠蓝斑核神经元中A型单胺氧化酶活性和中缝背核神经元中B型单胺氧化酶活性的优先定位:一项详细的酶组织化学研究。
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J Affect Disord. 1995 Dec 13;35(3):125-9. doi: 10.1016/0165-0327(95)00056-9.

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