Makris A, Ryan K J
Steroids. 1980 Jan;35(1):53-64. doi: 10.1016/0039-128x(80)90111-7.
The comparative ability of granulosa cells and theca of the hamster preovulatory follicle to produce androgens in vitro from endogenous and exogenous substrates was assessed. The results indicate that theca are the major source of follicular androstenedione, but that the granulosa cells may be the major source of follicular testosterone. Theca and granulosa cells accumulate comparable amounts of dihydrotestosterone from exogenous androstenedione and testosterone and both may be a significant source of follicular DHT. LH stimulates the conversion of progesterone and 17 alpha-OH progesterone to androstenedione, testosterone and DHT in theca. LH does not stimulate the conversion of androstenedione to testosterone or DHT, and that of testosterone to DHT in either granulosa cells or theca. FSH, in granulosa cells but not in theca, stimulates the conversion of adrostenedione to testosterone but it has no effect in DHT accumulation from exogenous testosterone.
评估了仓鼠排卵前卵泡的颗粒细胞和卵泡膜在体外从内源性和外源性底物产生雄激素的相对能力。结果表明，卵泡膜是卵泡雄烯二酮的主要来源，但颗粒细胞可能是卵泡睾酮的主要来源。卵泡膜和颗粒细胞从外源性雄烯二酮和睾酮中积累相当数量的双氢睾酮，两者都可能是卵泡双氢睾酮的重要来源。促黄体生成素（LH）刺激卵泡膜中孕酮和17α-羟孕酮转化为雄烯二酮、睾酮和双氢睾酮。促黄体生成素不刺激颗粒细胞或卵泡膜中雄烯二酮转化为睾酮或双氢睾酮，也不刺激睾酮转化为双氢睾酮。促卵泡生成素（FSH）在颗粒细胞中而非卵泡膜中刺激雄烯二酮转化为睾酮，但对从外源性睾酮积累双氢睾酮没有影响。
