Sebel P S, Kershaw E J, Rao W S
Br J Anaesth. 1980 Jan;52(1):81-4. doi: 10.1093/bja/52.1.81.
An i.v. solution of 5% dextrose with doxapram 2 mg ml-1 or 5% dextrose alone was administered to 53 patients following lateral thoracotomy. Estimations of arterial PO2, PCO2 and pH were made before operation, during infusion and 7 days after after operation. Respiratory function tests were carried out before and 7 days after operation. There were no significant differences in arterial PO2, PCO2 and pH or in respiratory function tests between those who received doxapram and those who did not. In this study doxapram did not affect the frequency of postoperative pulmonary complications.
对53例行侧胸切开术的患者静脉输注含2毫克/毫升多沙普仑的5%葡萄糖溶液或单纯的5%葡萄糖溶液。在手术前、输液期间及术后7天测定动脉血氧分压（PO2）、二氧化碳分压（PCO2）和pH值。在手术前和术后7天进行呼吸功能测试。接受多沙普仑治疗的患者与未接受多沙普仑治疗的患者在动脉PO2、PCO2、pH值或呼吸功能测试方面没有显著差异。在本研究中，多沙普仑不影响术后肺部并发症的发生率。
