[地塞米松对血管活性肠肽（VIP）诱导的催乳素释放的调节作用]
[Dexamethasone regulation of the prolactin release induced by vasoactive intestinal peptide (VIP)].
作者信息
Rotsztejn W, Benoist L, Besson J, Duval J
出版信息
C R Seances Acad Sci D. 1980 Mar 24;290(12):791-3.
PMID:6769606
Abstract
The regulation of prolactin (PRL) secretion induced by the vasoactive intestinal peptide (VIP) has been studied on purified male Rat Pituitary PRL cells obtained by means of velocity sedimentation at unit gravity. Dexamethasone (10(-9) M) in the incubation medium inhibits the stimulatory effect of VIP (10(-7) M) on PRL release. This result suggests that glucocorticoids play an important role in the regulation of VIP effects at the effects at the pituitary level.
摘要
通过单位重力下的速度沉降法获得纯化的雄性大鼠垂体催乳素（PRL）细胞，对血管活性肠肽（VIP）诱导的PRL分泌调节进行了研究。孵育培养基中的地塞米松（10^(-9) M）抑制VIP（10^(-7) M）对PRL释放的刺激作用。该结果表明糖皮质激素在垂体水平对VIP作用的调节中起重要作用。
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