Mohanty S, Ray A K, Dey P K
Indian J Physiol Pharmacol. 1980 Apr-Jun;24(2):91-6.
Cerebral oedema often occurs following trauma to the brain. Recently several biogenic amines have been suggested for their possible mediation in the pathophysiology of traumatic brain oedema. The present investigation indirectly indicates that prostaglandins of E series are also involved in the etiology of cerebral oedema, since administration of a potent PG synthetase inhibitor, indomethacin significantly diminished oedematous swelling of traumatised rat brain.
脑水肿常发生于脑外伤后。最近有几种生物胺被认为可能参与了创伤性脑水肿的病理生理过程。目前的研究间接表明，E系列前列腺素也参与了脑水肿的病因，因为给予一种强效的PG合成酶抑制剂吲哚美辛可显著减轻创伤大鼠脑的水肿肿胀。
