神经性厌食症患者促甲状腺激素和生长激素对促甲状腺激素释放激素的反应

Thyroid stimulating hormone and growth hormone responses to thyrotropin releasing hormone in anorexia nervosa.

作者信息

Gold M S, Pottash A L, Martin D M, Finn L B, Davies R K

出版信息

Int J Psychiatry Med. 1980;10(1):51-5. doi: 10.2190/xwrq-3tgc-cbe8-enb3.

Abstract

Ten female patients who satisfied objective criteria for the diagnosis of anorexia nervosa were given 500 microgram of thyrotropin releasing hormone. Thyroid stimulating hormone and growth hormone responses were measured in duplicate by radioimmunoassay. These patients had a low normal delta thyroid stimulating hormone but a delayed peak response. In addition, these patients had pathological growth hormone release in response to thytotropin releasing hormone infusion. Both delayed peak thyroid stimulating hormone and growth hormone response to thyrotropin releasing hormone have been reported for patients with hypothalamic disorders.

摘要

对10名符合神经性厌食症诊断客观标准的女性患者给予500微克促甲状腺激素释放激素。通过放射免疫分析法对促甲状腺激素和生长激素的反应进行了重复测量。这些患者的促甲状腺激素增量处于正常低水平，但峰值反应延迟。此外，这些患者在输注促甲状腺激素释放激素后出现病理性生长激素释放。下丘脑疾病患者已被报道存在促甲状腺激素峰值延迟和对促甲状腺激素释放激素的生长激素反应延迟的情况。