Bastenie P A, Bonnyns M, Vanhaelst L
J Clin Endocrinol Metab. 1980 Jul;51(1):163-6. doi: 10.1210/jcem-51-1-163.
Serum levels of T4 T3, and TSH and peak TSH after TRH administration were determined in 60 female subjects affected with asymptomatic autoimmune thyroiditis (AAT), in 27 normal subjects, and in 8 myxoedematous patients used as controls. The AAT subjects were divided into 3 groups on the basis of their basal and peak TSH values. In the first group (grade I AAT), these parameters were similar to those of the normal controls; in the second (grade II AAT), basal TSH remained normal but peak TSH was significantly increased; and in the third (grade III AAT), both parameters were significantly increased. Serum T4 levels decreased progressively from group 1 to group 3, but all T4 values were within the normal range. T3 levels were similar in all groups. Peak and basal TSH values were highly correlated, except in grade II AAT. There seems to exist a graded process of subclinical hypothyroidism in AAT; a progressive pituitary TSH reserve is modulated by a progressive decrease in T4 levels still within the normal range.
对60例患有无症状自身免疫性甲状腺炎（AAT）的女性受试者、27例正常受试者以及8例用作对照的黏液性水肿患者测定了血清T4、T3、促甲状腺激素（TSH）水平以及促甲状腺激素释放激素（TRH）给药后的TSH峰值。根据基础TSH值和TSH峰值，将AAT受试者分为3组。在第一组（Ⅰ级AAT）中，这些参数与正常对照组相似；在第二组（Ⅱ级AAT）中，基础TSH保持正常，但TSH峰值显著升高；在第三组（Ⅲ级AAT）中，两个参数均显著升高。血清T4水平从第1组到第3组逐渐降低，但所有T4值均在正常范围内。所有组的T3水平相似。除Ⅱ级AAT外，TSH峰值和基础值高度相关。AAT中似乎存在亚临床甲状腺功能减退的分级过程；仍在正常范围内的T4水平逐渐降低调节着垂体促甲状腺激素储备的逐步变化。
