Ioppoli C, Meucci G, Mariotti S, Martino E, Lippi A, Gironelli L, Pinchera A, Muratorio A
Istituto di Clinica Neurologica, Università di Pisa.
Ital J Neurol Sci. 1990 Feb;11(1):31-6. doi: 10.1007/BF02334902.
Multiple sclerosis (MS) is associated with complex abnormalities of immunoregulation and a role of autoimmunity in its pathogenesis has been accepted. MS is reportedly associated with several autoimmune diseases, but few studies are available on the prevalence of organ-specific autoantibodies in this condition. The aim of this study was to assess the frequency of anti-thyroglobulin (TgAb), anti-thyroid microsomal (MAb) and gastric parietal cell (PCA) antibodies in 113 patients (63 females, 50 males, age ranging 15-62 years) with MS and in 51 neurological controls. The diagnosis of MS was made according to McDonald and Halliday criteria. TgAb and/or MAb were detected by passive hemagglutination in 19 (16.8%) patients with MS and in 3 (5.9%) of the controls. All positive TgAb and/or MAb were observed in MS females (19/63 = 30.1%), with significantly higher frequency than in female controls (X2 = 5.15, p less than 0.025). The presence of circulating thyroid antibodies was higher in patients with clinically definite or progressive probable MS and in those with long standing disease. In contrast with thyroid antibodies, no difference in the frequency of PCA, as assessed by radioimmunoassay, was observed between MS and controls. These data support a specific association between thyroid autoimmunity and MS. The appearance of thyroid autoimmune phenomena seems to be related to the reliability of the diagnosis of MS and the duration of the disease.
多发性硬化症（MS）与免疫调节的复杂异常有关，自身免疫在其发病机制中的作用已被认可。据报道，MS与多种自身免疫性疾病相关，但关于这种情况下器官特异性自身抗体患病率的研究较少。本研究的目的是评估113例MS患者（63例女性，50例男性，年龄在15 - 62岁之间）和51例神经科对照者中抗甲状腺球蛋白（TgAb）、抗甲状腺微粒体（MAb）和胃壁细胞（PCA）抗体的频率。MS的诊断依据McDonald和Halliday标准。通过被动血凝试验在19例（16.8%）MS患者和3例（5.9%）对照者中检测到TgAb和/或MAb。所有阳性的TgAb和/或MAb均见于MS女性患者（19/63 = 30.1%），其频率显著高于女性对照者（X2 = 5.15，p < 0.025）。临床确诊或进展性可能MS患者以及病程较长的患者中循环甲状腺抗体的存在率更高。与甲状腺抗体不同，通过放射免疫测定评估，MS患者和对照者之间PCA频率没有差异。这些数据支持甲状腺自身免疫与MS之间存在特定关联。甲状腺自身免疫现象的出现似乎与MS诊断的可靠性和疾病持续时间有关。
