Conetta D A, Christie L G, Feldman R L, Nichols W W, Pepine C J, Conti C R
J Clin Ultrasound. 1980 Jun;8(3):233-8. doi: 10.1002/jcu.1870080309.
Simultaneous left ventricular echograms and high-gain pressure recordings were made during 30 s of regional myocardial ischemia induced by snare occlusions of the proximal left anterior descending (LAD) or left circumflex (LCx) coronary arteries in open-chest dogs. Left ventricular diastolic diameter (d) and pressure (p) were measured during slow filling. A normalized (for diameter D) distensibility estimate (DE = delta d/delta p/D) was calculated, as were slow filling slopes (SFSs) of the septum and posterior wall. After occlusion, significant (p less than 0.05) decreases of DE and anterior and posterior left-ventricular-wall mid-diastolic normalized slow-filling slopes (ASFS/D and PSFS/D) were observed. Correlations were noted between percentage decreases of DE and ASFS/D (r = 0.69, p less than 0.0001) and PSFS/D (r = 0.62, p less than 0.0001). No significant differences between decreases of DE and SFS were noted between ischemic and non-ischemic regions. Transient regional myocardial ischemia was associated with a generalized alteration in left ventricular filling patterns in mid-diastole.
在开胸犬中，通过圈套器阻塞左前降支（LAD）或左旋支（LCx）冠状动脉近端诱导30秒的局部心肌缺血，同时记录左心室超声心动图和高增益压力。在缓慢充盈期测量左心室舒张直径（d）和压力（p）。计算归一化（相对于直径D）的扩张性估计值（DE = Δd/Δp/D），以及室间隔和后壁的缓慢充盈斜率（SFSs）。阻塞后，观察到DE以及左心室前壁和后壁舒张中期归一化缓慢充盈斜率（ASFS/D和PSFS/D）显著（p<0.05）降低。注意到DE降低百分比与ASFS/D（r = 0.69，p<0.0001）和PSFS/D（r = 0.62，p<0.0001）之间存在相关性。缺血区和非缺血区之间，DE降低和SFS降低无显著差异。短暂性局部心肌缺血与舒张中期左心室充盈模式的普遍改变有关。
