雄性和雌性大鼠血管组织中的前列腺素合成酶活性
Prostaglandin synthetase activity in vascular tissue of male and female rats.
作者信息
Maggi F M, Tyrrell N, Maddox Y, Watkins W, Ramey E R, Ramwell P W
出版信息
Prostaglandins. 1980 Jun;19(6):985-93. doi: 10.1016/0090-6980(80)90131-8.
PMID:6770422
Abstract
- Isolated perfused lungs from mature male rats show greater conversion of 14C Arachidonic Acid to cyclo-oxygenase products than females. 2. Following unlabelled arachidonate infusion, the male lungs release more 6-K-PGF1 alpha and TxB2 than females. 3. Aortic rings from male rats release more PGI2-like material and 6-K-PGF1 alpha than the females. 4. These data indicate an elevated PG synthetase activity in male rats as compared with females.
摘要
- 来自成年雄性大鼠的离体灌注肺脏比雌性大鼠能将更多的14C花生四烯酸转化为环氧化酶产物。2. 注入未标记的花生四烯酸盐后，雄性肺脏比雌性释放更多的6-酮-前列腺素F1α和血栓素B2。3. 雄性大鼠的主动脉环比雌性释放更多的前列环素样物质和6-酮-前列腺素F1α。4. 这些数据表明，与雌性相比，雄性大鼠的前列腺素合成酶活性升高。
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