Henry R S, Jurgens R W, Sturgeon R, Athanikar N, Welco A, Van Leuven M
Am J Hosp Pharm. 1980 May;37(5):673-4.
The maximum concentrations of phosphate that will remain soluble in a parenteral nutrient solution containing various concentrations of calcium chloride or calcium gluconate were determined. Various concentrations of sodium phosphate were mixed with FreAmine II (McGaw Laboratories), and the resulting solutions were mixed with 50% dextrose solutions containing various concentrations of calcium chloride or calcium gluconate. The final solutions were sealed and stored at 30 degrees C for 24 hours and then were inspected visually for precipitate formation. It was found that higher equivalent concentrations of phosphate are attainable when calcium gluconate, instead of calcium chloride, is used as the calcium source. Factors found to influence the concentrations of calcium and phosphate that are compatible in amino acid solutions are the calcium salt used, temperature and duration of storage, dextrose concentration, amino acid composition, pH, and other additives.
测定了在含有不同浓度氯化钙或葡萄糖酸钙的肠外营养液中仍能保持溶解状态的磷酸盐的最大浓度。将不同浓度的磷酸钠与复方氨基酸注射液（麦高实验室）混合，然后将所得溶液与含有不同浓度氯化钙或葡萄糖酸钙的50%葡萄糖溶液混合。将最终溶液密封并在30℃下储存24小时，然后目视检查是否有沉淀形成。结果发现，当使用葡萄糖酸钙而非氯化钙作为钙源时，可以达到更高的磷酸盐当量浓度。发现影响氨基酸溶液中钙和磷酸盐相容性浓度的因素有所用的钙盐、储存温度和时间、葡萄糖浓度、氨基酸组成、pH值以及其他添加剂。
