Evans A J, Morrison G D, Price D J
Br J Vener Dis. 1980 Apr;56(2):88-91. doi: 10.1136/sti.56.2.88.
Of 1081 patients with gonorrhoea treated with probenecid 1 g orally and benzyl penicillin 5 megaunits intramuscularly, 96.7% were cured and no complications were encountered. This treatment regimen was associated with a pronounced reduction in the proportion of gonococcal strains showing diminished sensitivity to penicillin, from 51% to between 4% and 14% over a period of four years. When this treatment method was abandoned, however, the percentage of less sensitive strains rose to 33% over the following 18 months.
对1081例淋病患者采用丙磺舒1克口服加苄星青霉素500万单位肌内注射进行治疗,96.7%的患者治愈,且未出现并发症。在四年时间里,这种治疗方案使对青霉素敏感性降低的淋球菌菌株比例显著下降,从51%降至4%至14%之间。然而,当放弃这种治疗方法后,在接下来的18个月里,敏感性较低菌株的比例升至33%。