Funderburk S J, Guthrie D, Lind R C, Muller H M, Sparkes R S, Westlake J R
Am J Med Genet. 1978;1(3):301-8. doi: 10.1002/ajmg.1320010306.
The frequency of minor chromosome variants, as detected by conventional chromosome analysis, was examined among 1,289 child psychiatric patients, of whom one-fourth had only behavioral problems and three-fourths had congenital abnormalities and more severe mental disorders. There was no more than random association between prominent satellites, prominent secondary constrictions or a long Y chromosome, and congenital abnormalities or more severe mental disorders. The frequencies of these chromosome variants were affected by race as has been shown in previous studies. These findings do not support the evidence for a developmental effect of minor variants in man.
通过传统染色体分析检测到的微小染色体变异频率，在1289名儿童精神病患者中进行了检查，其中四分之一仅有行为问题，四分之三有先天性异常和更严重的精神障碍。显著卫星、显著次缢痕或长Y染色体与先天性异常或更严重的精神障碍之间不存在超过随机的关联。这些染色体变异的频率如先前研究所示受种族影响。这些发现不支持人类微小变异具有发育效应的证据。
