Shimizu K, Ohta T, Toda N
Stroke. 1980 May-Jun;11(3):261-6. doi: 10.1161/01.str.11.3.261.
In helically-cut strips of dog cerebral, coronary and mesenteric arteries, contracted with prostaglandin (PG) F2 alpha or K+, the addition of verapamil caused a dose-related relaxation. Verapamil-induced relaxations were greater in cerebral than in the other arteries when contracted with PGF2 alpha, but did not significantly differ in the arteries contracted with K+. Similar results were obtained with diltiazem and nifedipine. The contractile response to PGF2 alpha was attenuated by pretreatment with verapamil, the ateenuation being greater in cerebral than in mesenteric arteries. Nitroglycerin and sodium nitroprusside relaxed cerebral, coronary and mesenteric arteries contracted with PGF2 alpha to a similar extent. It may be concluded that dog cerebral arteries contracted with PGF2 alpha, one of endogenous vasospastic substances, are more susceptible to agents which interfere with the influx of Ca++ across cell membranes than coronary and mesenteric arteries; these agents may thus be of value in the treatment and prophylaxis of cerebral vasopasm.
在狗的脑动脉、冠状动脉和肠系膜动脉的螺旋形切片中，用前列腺素（PG）F2α或钾离子使其收缩后，加入维拉帕米会引起剂量相关的舒张。当用PGF2α收缩时，维拉帕米引起的舒张在脑动脉中比在其他动脉中更明显，但在用钾离子收缩的动脉中无显著差异。地尔硫䓬和硝苯地平也得到了类似的结果。维拉帕米预处理可减弱对PGF2α的收缩反应，这种减弱在脑动脉中比在肠系膜动脉中更明显。硝酸甘油和硝普钠使因PGF2α收缩的脑动脉、冠状动脉和肠系膜动脉舒张的程度相似。可以得出结论，与冠状动脉和肠系膜动脉相比，用内源性血管痉挛物质之一PGF2α收缩的狗脑动脉对干扰钙离子跨细胞膜内流的药物更敏感；因此这些药物可能在治疗和预防脑血管痉挛方面有价值。
