Miller J H, Sinatra F R, Thomas D W
AJR Am J Roentgenol. 1980 Jul;135(1):47-52. doi: 10.2214/ajr.135.1.47.
A new class of hepatobiliary imaging agents has become available--the N-substituted iminodiacetic acids. After intravenous administration, these compounds are quickly extracted by the hepatocytes and rapidly excreted into the biliary tree. By using a 99mTc label, sufficient activity may be given to allow excellent gamma-camera imaging, 99mTc-labeled p-isopropylacetanilido-iminodiacetic acid (PIPIDA) has been used in the evaluation of infants with biliary excretion disorders, including two infants with neonatal hepatitis, three with intrahepatic cholestatic jaundice, and 10 with biliary atresia. Follow-up evaluation of surgically created portoenterostomies has been performed as well. In comparison with the previously available agent (131I rose bengal), the marked reduction in radiation to the liver alone should predicate the use of 99mTc PIPIDA. In addition, the speed of handling of this agent by the liver and the vastly improved imaging statistics make 99mTc PIPIDA a desirable agent for the evaluation of biliary excretion disorders in infancy.
一类新型的肝胆显像剂已经问世——N-取代亚氨基二乙酸。静脉注射后，这些化合物会迅速被肝细胞摄取，并迅速排泄到胆管系统。通过使用99mTc标记，可以给予足够的放射性活度以进行出色的γ相机显像。99mTc标记的对异丙基乙酰苯胺基-亚氨基二乙酸（PIPIDA）已用于评估患有胆汁排泄障碍的婴儿，包括两名患有新生儿肝炎的婴儿、三名患有肝内胆汁淤积性黄疸的婴儿和十名患有胆道闭锁的婴儿。还对手术创建的肝门空肠吻合术进行了随访评估。与先前可用的显像剂（131I玫瑰红）相比，仅肝脏所接受辐射的显著减少就预示着应使用99mTc PIPIDA。此外，肝脏对该显像剂的处理速度以及大大改善的显像统计学结果使99mTc PIPIDA成为评估婴儿期胆汁排泄障碍的理想显像剂。
