Kameda Y, Ikeda A
Cell Tissue Res. 1980;208(3):417-32. doi: 10.1007/BF00233874.
The C-cell complexes are remnants of ultimobranchial bodies retaining fetal characteristics. They contain C cells in various stages of differentiation, primordial follicles with small lacunae, follicular cell masses not yet forming follicles, and undifferentiated epithelial cells. By immunoperoxidase method using specific anti-calcitonin, anti-C-thyroglobulin and anti-19S thyroglobulin sera, the responses of C-cell complexes to hypercalcemia, thiourea, hypophysectomy and hypercalcemia after hypophysectomy were investigated systematically. These experimental conditions induced rapid differentiation and increased numbers of cells in the complexes. After chronic hypercalcemia, most of the complexes were occupied by mature C cells. The C cells in complexes similar to the cells in thyroid parenchyma presented increased mitotic activity, enlarged cell bodies and a marked decrease in materials immunoreactive for calcitonin and C-thyroglobulin. After prolonged administration of thiourea, follicular cell masses and small follicles, which underwent conspicuous hyperplasia and hypertrophy, markedly increased in the complexes and exceeded C cells in number. Typical undifferentiated cells were not recognized after hypercalcemia and treatment with thiourea, though they were unaffected by hypophysectomy. It is considered that undifferentiated cells develop into C cells after hypercalcemia and into follicular cells after treatment with thiourea; that is, undifferentiated cells seem to be the common precursor cell for both C cells and follicular cells.
C细胞复合体是保留胎儿特征的鳃后体残余物。它们包含处于不同分化阶段的C细胞、带有小腔隙的原始卵泡、尚未形成卵泡的卵泡细胞团以及未分化的上皮细胞。通过使用特异性抗降钙素、抗C甲状腺球蛋白和抗19S甲状腺球蛋白血清的免疫过氧化物酶方法，系统地研究了C细胞复合体对高钙血症、硫脲、垂体切除以及垂体切除后的高钙血症的反应。这些实验条件诱导了复合体中细胞的快速分化并增加了细胞数量。慢性高钙血症后，大多数复合体被成熟的C细胞占据。复合体中的C细胞与甲状腺实质中的细胞相似，其有丝分裂活性增加、细胞体增大，并且对降钙素和C甲状腺球蛋白呈免疫反应的物质显著减少。长期给予硫脲后，复合体中经历明显增生和肥大的卵泡细胞团和小卵泡显著增加，数量超过C细胞。高钙血症和硫脲处理后未识别出典型的未分化细胞，尽管它们不受垂体切除的影响。据认为，未分化细胞在高钙血症后发育为C细胞，在硫脲处理后发育为卵泡细胞；也就是说，未分化细胞似乎是C细胞和卵泡细胞的共同前体细胞。
