Duchen M R, McNeilly A S
Clin Endocrinol (Oxf). 1980 Jun;12(6):621-7. doi: 10.1111/j.1365-2265.1980.tb01384.x.
Clinical details of lactational and menstrual history post-partum have been correlated with measurements of serum prolactin, luteinizing hormone, follicle stimulating hormone, oestradiol and progesterone in Transkei women in order to gain further insight into the role of prolactin in the maintenance of post-partum lactational amenorrhoea. Of seventy-four breast-feeding mothers studied, sixty-six had elevated serum levels of prolactin. Forty-four women were amenorrhoeic with minimal or absent endocrine evidence of ovarian activity. Of the twenty-seven lactating women who reported menstruation, twelve had high levels of prolactin and no apparent ovarian activity, eleven had lower prolactin levels and increased oestradiol levels suggesting ovarian follicular development, while only four women had increased progesterone levels indicating definite luteal activity. Three lactating women were pregnant. The results support previous reports that lactational amenorrhoea is associated with hyperprolactinaemia and a possible sequence of endocrine events resulting in the return of post-partum fertility is proposed.
为了进一步深入了解催乳素在维持产后哺乳期闭经中的作用，已将特兰斯凯女性产后的哺乳和月经史临床细节与血清催乳素、促黄体生成素、促卵泡激素、雌二醇和孕酮的测量结果进行了关联。在研究的74名母乳喂养母亲中，66名母亲的血清催乳素水平升高。44名女性闭经，卵巢活动的内分泌证据极少或不存在。在报告有月经的27名哺乳期女性中，12名催乳素水平高且无明显卵巢活动，11名催乳素水平较低但雌二醇水平升高，提示有卵泡发育，而只有4名女性孕酮水平升高，表明有明确的黄体活动。3名哺乳期女性怀孕。这些结果支持了先前的报告，即哺乳期闭经与高催乳素血症有关，并提出了导致产后生育能力恢复的可能内分泌事件序列。
