Benedetti M S, Ancher J F, Sontag N
Experientia. 1980 Jul 15;36(7):818-10. doi: 10.1007/BF01978589.
In rat, histamine metabolism is altered by some nonspecific inhibitors of monoamine oxidase (MAO) such as iproniazid, and, to a lesser extent, tranylcypromine. Type A MAO inhibitors, such as clorgyline and MD780515, do not seem to interfere with the metabolism of histamine. Deprenyl, a type B MAO inhibitor, shows some inhibition which is, however, much lower than that observed with iproniazid. The strong effect of iproniazid is probably due to its DAO inhibiting properties.
在大鼠中，组胺代谢会被一些单胺氧化酶（MAO）的非特异性抑制剂所改变，如异烟肼，以及在较小程度上被反苯环丙胺改变。A型MAO抑制剂，如氯吉兰和MD780515，似乎不会干扰组胺的代谢。B型MAO抑制剂司来吉兰表现出一定的抑制作用，然而，其抑制作用远低于异烟肼所观察到的效果。异烟肼的强烈作用可能归因于其对二胺氧化酶（DAO）的抑制特性。
