Land R B, Carr W R, McNeilly A S, Preece R D
J Reprod Fertil. 1980 May;59(1):73-8. doi: 10.1530/jrf.0.0590073.
The effects of pharmacological reduction of the high plasma prolactin concentration typical of seasonal anoestrus in sheep were assessed with respect to positive feedback of oestrogen on LH release, ovulation, and progesterone secretion. Treatment of 16 Scottish Blackface ewes with 1 mg bromocriptine, i.m. twice daily for 12 days, reduced prolactin concentrations in peripheral plasma from 64 +/- 10 ng/ml before treatment to < 4 ng/ml. This treatment had no effect on the proportion of ewes discharging LH and FSH in response to 12.5 microgram oestradiol benzoate (3/8 before compared with 5/16 during treatment) or the proportion of ewes ovulating in response to oestrogen treatment. Plasma progesterone concentrations remained low even in ovulating ewes. It is concluded that treatment with bromocriptine alone is unlikely to restore oestrous cycles to ewes in seasonal anoestrus.
就雌激素对促黄体生成素（LH）释放、排卵及孕酮分泌的正反馈作用而言，评估了药物降低绵羊季节性乏情典型的高血浆催乳素浓度的效果。对16只苏格兰黑脸母羊每天两次肌肉注射1毫克溴隐亭，持续12天，外周血浆中的催乳素浓度从治疗前的64±10纳克/毫升降至<4纳克/毫升。该治疗对接受12.5微克苯甲酸雌二醇后释放LH和促卵泡激素（FSH）的母羊比例（治疗前3/8，治疗期间5/16）或接受雌激素治疗后排卵的母羊比例没有影响。即使在排卵的母羊中，血浆孕酮浓度仍保持较低水平。得出的结论是，单独使用溴隐亭治疗不太可能使季节性乏情的母羊恢复发情周期。
