两栖动物化学诱导性肌强直

Chemically induced myotonia in amphibia.

作者信息

Bretag A H, Dawe S R, Moskwa A G

出版信息

Nature. 1980 Aug 7;286(5773):625-6. doi: 10.1038/286625a0.

Abstract

Frogs and toads treated with high doses of anthracene-9-carboxylic acid (A-9-C) develop prolonged muscular contractions and 'divebomber' electromyograms characteristic of myotonia. Hitherto, myotonia has been considered peculiar to homeotherms where it is associated with several hereditable diseases and can be induced by specific treatments, most of which seem to act by decreasing membrane chloride conductance. Our work indicates that myotonia can be induced in amphibia by similar means. We offer possible reasons why others have missed seeing myotonia in amphibia.

摘要

用高剂量的蒽-9-羧酸（A-9-C）处理青蛙和蟾蜍后，它们会出现长时间的肌肉收缩以及强直性肌电图特征的“俯冲轰炸机”样肌强直。迄今为止，肌强直一直被认为是恒温动物所特有的，在恒温动物中它与几种遗传性疾病有关，并且可以通过特定的处理诱导产生，其中大多数处理似乎是通过降低膜氯电导来起作用的。我们的研究表明，类似的方法也可以在两栖动物中诱导出肌强直。我们给出了为什么其他人没有在两栖动物中发现肌强直的可能原因。