[Effect of partial modification of serum albumin on its conformation and complex-forming activity].

In using a series of the succinic anhydride concentration the authors obtained preparations of succinylated albumin with a different degree of modification. The effect of succinylation on the immunochemical and some physico-chemical properties of albumin were investigated; depending on the concentration of the modifying reagent preparations of succinylated albumin proved to differ by the antigenic properties, electrophoretic mobility in agar gel and the complex-forming activity in interaction with rivanol. Conditions of partial modification permitting to increase the complex-forming properties of albumin 3-fold with the minimal changes in its structure were determined.