Dzoljic M R, van der Poel-Heisterkamp A L
Pharmacol Biochem Behav. 1980 Jul;13(1):103-6. doi: 10.1016/0091-3057(80)90127-6.
Local administration of the enkephalin-analog. D-Ala2-Met5-enkephalinamide (DALA) into the nucleus accumbens and caudate nucleus of the rat resulted in myoclonic contrations (MC) of the submandibular muscles and epileptic discharges in the electrocorticogram. These phenomena were blocked by naloxone but not by haloperidol. Similar administration of DALA into the substantia nigra compacta failed to produce MC. A possible involvement of endogenous opiates in the nucleus accumbens and striatum is suggested in the pathogenesis of some types of myoclonus.
将脑啡肽类似物D-丙氨酸²-甲硫氨酸⁵-脑啡肽酰胺（DALA）局部注射到大鼠的伏隔核和尾状核中，会导致下颌下肌肉的肌阵挛性收缩（MC）以及脑电图中的癫痫样放电。这些现象可被纳洛酮阻断，但不能被氟哌啶醇阻断。将DALA类似地注射到黑质致密部中未能产生MC。提示内源性阿片类物质可能参与伏隔核和纹状体，在某些类型肌阵挛的发病机制中发挥作用。
