Goldfinger D, Capostagno V, Lowe C, Sacks H J, Gatti R A
Transfusion. 1980 Jul-Aug;20(4):450-4. doi: 10.1046/j.1537-2995.1980.20480260279.x.
We used repeated leukapheresis in the long-term management of chronic lymphocytic leukemia. Twelve patients with far-advanced disease that was refractory to standard forms of therapy, were studied. Six patients completed a predefined course of therapy. Although a single patient responded favorably for a period of time, no other patient was benefited by this treatment. While circulating lymphocyte counts in these patients always could be reduced, generally, this was not associated with improvements in pancytopenia, hypogammagobulinemia, adenopathy, organomegaly, or constitutional symptoms of lethargy, fevers and night sweats. Mean survival was only ten months from onset of therapy. We conclude that long-term leukapheresis is ineffective in the management of far-advanced chronic lymphocytic leukemia.
我们采用重复白细胞单采术对慢性淋巴细胞白血病进行长期治疗。研究了12例病情严重且对标准治疗方法无效的患者。6例患者完成了预定的治疗疗程。虽然有1例患者在一段时间内反应良好，但其他患者均未从该治疗中获益。虽然这些患者的循环淋巴细胞计数总能降低，但总体而言，这与全血细胞减少、低丙种球蛋白血症、淋巴结病、脏器肿大或乏力、发热和盗汗等全身症状的改善无关。从治疗开始算起，平均生存期仅10个月。我们得出结论，长期白细胞单采术对晚期慢性淋巴细胞白血病的治疗无效。
