Raĭkis B N, Ugrimov S A, Makhinovskaia F L, Illiutovich N A
Biull Eksp Biol Med. 1980 Aug;90(8):197-8.
It was shown that allergoid, a preparation with decreased allergenicity and preserved immunogenicity, can be produced from ragweed growing in Stavropol. A comparative study of variations in the antigenic properties of the allergen under the effect of the temperature factor alone or a combination of the latter with formaldehyde allowed a conclusion that formaldehyde selectively neutralizes the antigenic determinants responsible for allergenicity. At the same time allergoid preserves its ability to induce antibody specific for the initial allergen in the rabbit.
结果表明，变应原样物质，一种变应原性降低而免疫原性保留的制剂，可以从斯塔夫罗波尔生长的豚草中制备。单独温度因素或温度因素与甲醛联合作用下变应原抗原特性变化的比较研究得出结论，甲醛选择性地中和了负责变应原性的抗原决定簇。同时，变应原样物质保留了在兔体内诱导针对初始变应原的特异性抗体的能力。
