Frelat G, Dassa E, Boquet P L
C R Seances Acad Sci D. 1980 Jun 9;290(21):1365-8.
The Mueller Hinton medium does not allow the growth of Escherichia coli Thy- strains. This effect is due to the presence of uridine (or a derived compound) which interferes with the function of thymidine phosphorylase. The presence of sulphonamides, in some E. coli K12 Thy- mutants, overcomes this inhibition. The same phenomenon of rescue by sulphonamides has been reproduced in a minimal medium containing thymine and uridine. The biochemical and clinical implications of this observation are discussed.
穆勒-欣顿培养基不允许大肠杆菌胸苷营养缺陷型菌株生长。这种效应是由于尿苷（或一种衍生化合物）的存在，它会干扰胸苷磷酸化酶的功能。在一些大肠杆菌K12胸苷营养缺陷型突变体中，磺胺类药物的存在可克服这种抑制作用。在含有胸腺嘧啶和尿苷的基本培养基中也重现了磺胺类药物的这种挽救现象。本文讨论了这一观察结果的生化和临床意义。
