[从头脂肪生成：氚水（³H）在雄性大鼠肝脏、血浆、脂肪组织和胴体中脂肪酸及总脂质的体内掺入动力学]
[De novo lipogenesis: kinetics of in vivo incorporation of tritiated water 3H into fatty acids and total lipids of the liver, plasma, adipose tissue and carcass of the male rat].
作者信息
Gandemer G, Pascal G, Durand G
出版信息
C R Seances Acad Sci D. 1980 Jun 23;290(23):1479-82.
PMID:6773685
Abstract
Tritiated water 3H, injected by intraperitoneal route into 7-week old male Rats, was incorporated into lipids synthesized de novo. The Rats were killed 0, 3, 7, 10, 15, 30, 60 and 120 min. after tracer injection. The results show that an optimal interval of about 10 min. between tracer injection and animal sacrifice was necessary to obtain a correct estimate of lipogenesis de novo by avoiding intertissue exchanges.
摘要
通过腹腔注射途径将氚水（³H）注入7周龄雄性大鼠体内，其被整合到新合成的脂质中。在注射示踪剂后0、3、7、10、15、30、60和120分钟处死大鼠。结果表明，为了通过避免组织间交换来正确估计从头脂肪生成，在注射示踪剂和处死动物之间需要约10分钟的最佳间隔。
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