Sorimachi K
Endocrinol Jpn. 1980 Apr;27(2):209-14. doi: 10.1507/endocrj1954.27.209.
Inhibitory effects of unlabeled iodothyronines on the metabolism of thyroxine (T4), 3,3',5-triiodothyronine (T3) and 3,3',5'-triiodothyronine (reverse T3, rT3) were investigated in continuously cultured monkey hepatocarcinoma cells which showed a rapid metabolism of the thyroid hormones. Nonphenolic ring deiodination of [3',5'-125I]-T4 and [3'-125I]-T3 was strongly inhibited by excess T3, 3,5-diiodothyronine (3,5-T2) and T4, whereas rT3 was the least effective inhibitor. Phenolic ring deiodination of [3,5'-125I]-rT3 was strongly affected by excess unlabeled rT3. However, the inhibitory effect of T4, T3 and 3,5-T3 was much weaker than that of rT3. It was concluded that rT3 is apparently the most effective inhibitor of phenolic ring deiodination but the least effective inhibitor of nonphenolic ring deiodination.
在持续培养的猴肝癌细胞中研究了未标记的碘甲状腺原氨酸对甲状腺素（T4）、3,3',5-三碘甲状腺原氨酸（T3）和3,3',5'-三碘甲状腺原氨酸（反式T3，rT3）代谢的抑制作用，这些细胞显示出甲状腺激素的快速代谢。过量的T3、3,5-二碘甲状腺原氨酸（3,5-T2）和T4强烈抑制[3',5'-125I]-T4和[3'-125I]-T3的非酚环脱碘作用，而rT3是最无效的抑制剂。过量未标记的rT3对[3,5'-125I]-rT3的酚环脱碘作用有强烈影响。然而，T4、T3和3,5-T3的抑制作用比rT3弱得多。得出的结论是，rT3显然是酚环脱碘作用最有效的抑制剂，但是非酚环脱碘作用最无效的抑制剂。
