Jacobsen W, Brauer F, Smith L L
Am J Surg. 1978 Jul;136(1):141-4. doi: 10.1016/0002-9610(78)90214-3.
Twelve patients undergoing vascular surgery were administered heparin according to preexisting protocols. The response to heparin and the rate of decay were measured by use of the activated coagulation time (ACT). The results showed a significant patient variability to response to and decay of heparin. In addition, a dose-response curve for heparin administration was established in sixteen patients undergoing vascular surgery. The ACT proved to be a simple and accurate monitor of heparin activity. It also made possible a steady state of anticoagulation throughout the duration of the vascular procedure. The reversal of the heparin effect could also be precisely determined by this test.
12名接受血管手术的患者按照既定方案给予肝素。通过活化凝血时间（ACT）来测量对肝素的反应和衰减率。结果显示，患者对肝素的反应和衰减存在显著差异。此外，为16名接受血管手术的患者建立了肝素给药的剂量反应曲线。ACT被证明是一种简单而准确的肝素活性监测指标。它还使得在整个血管手术过程中能够维持稳定的抗凝状态。通过该测试也能够精确确定肝素作用的逆转情况。
